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Virtually all patients with angioedema experience swellings of the skin. Most commonly affected are the extremities (arms, legs, hands, feet), the face and the genital organs. The trunk may also be affected. These swellings are not life-threatening but can prove a great hindrance to a normal life.

Frequently, swelling attacks are associated with, or preceded by, tingling, a feeling or tightness and/or pain. However, pruritus (itching) is absent and patients do not develop wheals, as is typical for histamine-mediated angioedema (see also Swellings may affect single regions of the body or develop simultaneously in more than one area.